Comments (0) El viernes 10 de noviembre, la Comunidad educativa de la Facultad de Ciencias Químicas, acompañó en una Misa en acción de gracias, un emotivo acto y un cálido brindis, a los alumnos que terminaron de cursar las Carreras de Bioquímica, Farmacia y Licenciatura en Tecnología de los Alimentos.
Prevención de Micosis Superficiales a cargo de los alumnos de la carrera de Bioquímica de la Cátedra de Micología
Una vez más los alumnos de 3º año de Bioquímica acompañaron al Centro de Salud 97 en una semana muy especial para las mujeres de Barrio Cabildo
Dr. Constantinos Athanassopoulos de la Universidad de Patras, Grecia.
Martes 31 de octubre a las 10 hs.
Aula de Postgrado B, Edificio de Ciencias Políticas, Campus UCC
Cancer stem cells (CSCs) are a subpopulation of cancer cells with high clonogenic capacity and ability to reform parental tumors upon transplantation. Several types of CSCs have shown resistance to chemotherapy and therefore they have been “accused” for causing tumor relapse. In the last decade many efforts have been made to design molecules, able to specifically target CSCs and to differentiate them or sensitize them to therapy. Among the different potential targets a special attention has been payed to the “Hedgehog pathway (Hh)”, which has emerged as a favourable target to address drug resistance in CSCs. Up to now a variety of natural, natural-derived (e.g. Cyclopamine) and synthetic origin molecules (e.g. Sonidegib, Vismodegib) have shown Hh inhibitory activity. Inhibitors of Gli1, the terminal effector of the pathway, are anticipated to evade drug resistance and to display fewer side effects than inhibitors targeting Smothened protein (Smo). Inspired by the Gli-mediated transcription inhibitor Taepeenin D we performed synthesis and evaluation of a series of analogues, which has led to key structure–activity relationships for this natural product. The information derived from this research will be discussed in the lecture.
Abietanes are a family of naturally occurring diterpenoids with a highly diverse repertoire of associated bioactivities. They have generated significant interest from the medicinal and pharmacological communities since they exhibit anticancer, antiviral, antifungal and antibacterial activity. Especially the latter is potentially valuable in the battle against the antimicrobial resistance and imminent antibiotic shortage. Recent results of Prof. Carpinella’s group demonstrated that an extract from Lepechinia meyenii exhibited an outstanding selectivity against a panel of methicillin-resistant Staphylococcus aureus (MRSA) strains. Bioguided fractionation led to the isolation of carnosol and rosmanol as its active principles. Prompted from these results and aiming at the development of new and more effective antimicrobial agents we synthesised a library of abietane analogues, using carnosic and abietic acid as the natural precursors, suitable for structure-activity relationship studies (SARS). Two promising compounds with MIC values against multi-resistant bacteria lower than that observed for the lead compounds, were identified from the abietic acid derivatives. Very interesting results regarding the structural elements responsible for the activity improvement were obtained. A second generation of derivatives, as well as, the evaluation of the carnosic acid derivatives are in progress. The results obtained will be discussed in detail.
Informes:
Secretaría de Posgrado
Facultad de Ciencias Químicas
cqadminpos@ucc.edu.ar
Inscripción via web:
https://age.ucc.edu.ar/web/siuccweb_php/ingre_ucc1.php
Ciencia, reencuentros, afectos y camaradería se dieron cita en Buenos Aires, donde alumnos, exalumnos y docentes compartieron el 72º Congreso Argentino de Bioquímica del 22 al 25 de agosto.
La Pastoral UCC, junto a chicos y chicas de Ciencias Químicas, Veterinaria, Ingeniería, Derecho, Ciencias Políticas y alumnos de la UNC, misionamos en San Francisco del Chañar, desde el viernes 18 al domingo 20 de agosto, ofreciendo lo más importante para un niño: nuestro tiempo. Compartimos abrazos, juegos, bailes y volvimos con el corazón lleno de emociones.
Súmate a la Pastoral y seguiremos ampliando recuerdos inolvidables!
