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By cienciasquimicas, 26/02/2019 14:04

Cátedra abierta de la carrera de Especialización en Tecnología de los Alimentos.

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By cienciasquimicas, 25/02/2019 14:08

Cátedra abierta de la Carrera de Especialización en Tencnología de los Alimentos.

Dirigido a: Profesionales interesados en gestión de la innovación en empresas de alimentos.

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By cienciasquimicas, 25/02/2019 14:03

A través de diferentes instancias de formación, la Fundación Jean Sonet de la UCC responde de forma activa a las necesidades del mercado laboral y profesional, garantizando la promoción de las habilidades y el intercambio de conocimientos.

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By cienciasquimicas, 16/10/2018 22:43

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By cienciasquimicas, 05/10/2018 16:09

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By cienciasquimicas, 04/10/2018 11:32

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By cienciasquimicas, 24/09/2018 17:40

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By cienciasquimicas, 22/09/2018 15:19

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By cienciasquimicas, 21/11/2017 18:46

Hasta el 24 de noviembre se encuentra abierta la convocatoria a Tecnobecas, un programa cuyo objetivo principal es brindar oportunidades de formación en actividades científicas, tecnológicas y de gestión a estudiantes avanzados y profesionales egresados recientemente. Durante 12 meses, los tecnobecarios seleccionados se desempeñarán en áreas y unidades afines a las disciplinas de su conocimiento, bajo la conducción de Directores que acompañarán el proceso de capacitación y práctica dentro del CEPROCOR.
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By cienciasquimicas, 24/10/2017 16:32

Conferencias:

• Targeting drug resistance in cancer stem cells – Hedgehog pathway inhibitors – Taepeenin D.

• Abietane diterpenes – high value natural precursors for the development of new antimicrobial agents.

Disertante:

Dr. Constantinos Athanassopoulos de la Universidad de Patras, Grecia. 

Fecha y horario:

Martes 31 de octubre a las 10 hs.

Lugar:

Aula de Postgrado B,  Edificio de Ciencias Políticas, Campus UCC

Resúmenes:

• Targeting drug resistance in cancer stem cells – Hedgehog pathway inhibitors – Taepeenin D

Cancer stem cells (CSCs) are a subpopulation of cancer cells with high clonogenic capacity and ability to reform parental tumors upon transplantation. Several types of CSCs have shown resistance to chemotherapy and therefore they have been “accused” for causing tumor relapse. In the last decade many efforts have been made to design molecules, able to specifically target CSCs and to differentiate them or sensitize them to therapy. Among the different potential targets a special attention has been payed to the “Hedgehog pathway (Hh)”, which has emerged as a favourable target to address drug resistance in CSCs. Up to now a variety of natural, natural-derived (e.g. Cyclopamine) and synthetic origin molecules (e.g. Sonidegib, Vismodegib) have shown Hh inhibitory activity. Inhibitors of Gli1, the terminal effector of the pathway, are anticipated to evade drug resistance and to display fewer side effects than inhibitors targeting Smothened protein (Smo). Inspired by the Gli-mediated transcription inhibitor Taepeenin D we performed synthesis and evaluation of a series of analogues, which has led to key structure–activity relationships for this natural product. The information derived from this research will be discussed in the lecture.

• Abietane diterpenes – high value natural precursors for the development of new antimicrobial agents

Abietanes are a family of naturally occurring diterpenoids with a highly diverse repertoire of associated bioactivities. They have generated significant interest from the medicinal and pharmacological communities since they exhibit anticancer, antiviral, antifungal and antibacterial activity. Especially the latter is potentially valuable in the battle against the antimicrobial resistance and imminent antibiotic shortage. Recent results of Prof. Carpinella’s group demonstrated that an extract from Lepechinia meyenii exhibited an outstanding selectivity against a panel of  methicillin-resistant Staphylococcus aureus (MRSA) strains. Bioguided fractionation led to the isolation of carnosol and rosmanol as its active principles. Prompted from these results and aiming at the development of new and more effective antimicrobial agents we synthesised a library of abietane analogues, using carnosic and abietic acid as the natural precursors, suitable for structure-activity relationship studies (SARS). Two promising compounds with MIC values against multi-resistant bacteria lower than that observed for the lead compounds, were identified from the abietic acid derivatives. Very interesting results regarding the structural elements responsible for the activity improvement were obtained. A second generation of derivatives, as well as, the evaluation of the carnosic acid derivatives are in progress. The results obtained will be discussed in detail.

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By cienciasquimicas, 02/10/2017 16:11

Clases inician en Febrero de 2018.
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By cienciasquimicas, 21/07/2017 17:39

Clases inician en agosto.

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